Derangement Speakers are dangerous enemies as they emit a specific frequency that slowly drains Aya's MP. They do not attack but when paired with enemies like Watchers or the Puppet Stinger in its boss fight they can prove to be a pain.
The easiest way of dealing with them is to use Energy Shot 3 and use the Grenade Pistol or the M203 as this will destroy them in one shot. They should be taken out quickly as machines do not give BP or MP which is important to note. If they are left alive for too long, they can become a major pain.