Central Park is a location in Parasite Eve, where Eve flees to after the events of Day 1, to pursue Melissa's Christmas concert, and is the major 'dungeon' for Day 2's events.

After the beginning of Day 2, Eve is reported in the park as Aya and Daniel Dollis return from encountering Hans Klamp at the museum, and Daniel swiftly rushes to save his son, Ben, and his ex-wife Lorraine. Aya gives chase to Daniel before he can enter the park, and stops him from going in as his arm begins to combust, thus been given the task to save his family and subdue Eve alone.

In the beginning of Day 2, Ben had concert tickets for his father, mother, and himself so they could try to be a family again, but Daniel, being caught up in the Eve case and the natural line of NYPD work, Daniel had let it slip his mind, causing Ben to run off with his mother into the park for the concert. However, before the concert had began, Ben begin to feel ill, and left the concert before Eve could convert the entire audience into a slime mass.

While Aya is investigating this area, Eve appears before her and convinces her to take a horse-drawn carriage so they may talk. Instead, Eve makes the horse spontaneously combust and battles Aya while the horse takes off with her inside. The battle lasts around the outside of the park until Eve disappears and Aya's left with the burning horse and the rampant carriage, where the heroine is knocked out, and is later found by Maeda.